英国伦敦大学学院G David Batty研究小组取得一项新突破。他们的最新研究对英国生物库与不同应答率的其他代表性研究进行了比较，以观察风险因素关联是否有差异。2020年2月12日，国际知名学术期刊《英国医学杂志》发表了这一成果。

为了比较基线调查低应答率的英国生物库与常规应答率的代表性研究中风险因素与死亡率之间的关联，研究组在英国进行了一项前瞻性队列研究及其他队列研究的荟萃分析。

英国生物库分析了499701人的样本（应答率为5.5%），英格兰健康调查（HSE）和苏格兰健康调查（SHS）的汇总数据包括18项研究和89895人（平均应答率为68%）。两个研究人群的基线年龄范围为40-69岁。

英国生物库的风险因素水平和死亡率分析模式优于HSE-SHS联合组。英国生物库在平均7.0年的随访中有14 288人死亡，HSE-SHS在超过10年的随访中有7861人死亡。心血管疾病死亡率方面，英国生物库经年龄和性别调整后吸烟（与从未吸烟相比）的危险比为2.04，HSE-SHS联合组为1.99，相差不大。当结果分别按性别、基线年数和审查日期统计时，上述结论不变。

总之，虽然英国生物库的应答率很低，但风险因素关联似乎具有普遍性，与传统队列研究相差不大。

附：英文原文

Title: Comparison of risk factor associations in UK Biobank against representative, general population based studies with conventional response rates: prospective cohort study and individual participant meta-analysis

Author: G David Batty, Catharine R Gale, Mika Kivimki, Ian J Deary, Steven Bell

Issue&Volume: 2020/02/12

Abstract:

Objective To compare established associations between risk factors and mortality in UK Biobank, a study with an exceptionally low rate of response to its baseline survey, against those from representative studies that have conventional response rObjective To compare established associations between risk factors and mortality in UK Biobank, a study with an exceptionally low rate of response to its baseline survey, against those from representative studies that have conventional response rates.

Design Prospective cohort study alongside individual participant meta-analysis of other cohort studies.

Setting United Kingdom.

Participants Analytical sample of 499?701 people (response rate 5.5%) in analyses in UK Biobank; pooled data from the Health Surveys for England (HSE) and the Scottish Health Surveys (SHS), including 18 studies and 89?895 people (mean response rate 68%). Both study populations were linked to the same nationwide mortality registries, and the baseline age range was aligned at 40-69 years.

Main outcome measure Death from cardiovascular disease, selected malignancies, and suicide. To quantify the difference between hazard ratios in the two studies, a ratio of the hazard ratios was used with HSE-SHS as the referent.

Results Risk factor levels and mortality rates were typically more favourable in UK Biobank participants relative to the HSE-SHS consortium. For the associations between risk factors and mortality endpoints, however, close agreement was seen between studies. Based on 14?288 deaths during an average of 7.0 years of follow-up in UK Biobank and 7861 deaths over 10 years of mortality surveillance in HSE-SHS, for cardiovascular disease mortality, for instance, the age and sex adjusted hazard ratio for ever having smoked cigarettes (versus never) was 2.04 (95% confidence interval 1.87 to 2.24) in UK Biobank and 1.99 (1.78 to 2.23) in HSE-SHS, yielding a ratio of hazard ratios close to unity (1.02, 0.88 to 1.19). The overall pattern of agreement between studies was essentially unchanged when results were compared separately by sex and when baseline years and censoring dates were aligned.

Conclusion Despite a very low response rate, risk factor associations in the UK Biobank seem to be generalisable.ates.

DOI: 10.1136/bmj.m131

Source: https://www.bmj.com/content/368/bmj.m131