近日，日本京都大学Mitinori Saitou及其课题组发现，ZGLP1是小鼠卵源命运的决定因素。相关论文2020年2月12日在线发表在《科学》上。

研究人员发现ZGLP1，一个具有GATA样锌指的保守转录调节因子，决定了小鼠的卵源命运。ZGLP1在骨形态发生蛋白（BMP）的下游起作用，但在视黄酸（RA）却不起作用，并且对于卵子程序和减数分裂至关重要。ZGLP1过表达通过激活由Polycomb活性抑制的卵母细胞程序来诱导体外原始生殖细胞样细胞（PGCLC）分化为胎儿卵母细胞，而RA信号有助于卵母细胞程序成熟和PGC程序抑制。这些发现阐明了哺乳动物卵原命运的决定机制，并为促进体外配子发生和生殖医学提供了基础。

据悉，哺乳动物的有性生殖依赖于雄性和雌性生殖细胞发育的分开。但是，其潜在机制仍不清楚。

附：英文原文

Author: So I. Nagaoka, Fumio Nakaki, Hidetaka Miyauchi, Yoshiaki Nosaka, Hiroshi Ohta, Yukihiro Yabuta, Kazuki Kurimoto, Katsuhiko Hayashi, Tomonori Nakamura, Takuya Yamamoto, Mitinori Saitou

Issue&Volume: 2020/02/13

Abstract: AbstractMammalian sexual reproduction relies on the dichotomy of male and female germ cell development. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate in mice. ZGLP1 acts downstream of bone morphogenetic protein (BMP), but not retinoic acid (RA), and is essential for the oogenic program and meiotic entry. ZGLP1 overexpression induces differentiation of in vitro primordial germ cell-like cells (PGCLCs) into fetal oocytes by activating the oogenic programs repressed by Polycomb activities, whereas RA signaling contributes to the oogenic program maturation and PGC program repression. Our findings elucidate the mechanism for mammalian oogenic fate determination, providing a foundation for promoting in vitro gametogenesis and reproductive medicine.

DOI: 10.1126/science.aaw4115

Source: https://science.sciencemag.org/content/early/2020/02/12/science.aaw4115