英国伦敦大学学院Michael Häusser、Nick T.M. Robinson等研究人员合作发现,海马位置细胞的靶向激活驱动记忆引导的空间行为。2020年11月6日,《细胞》在线发表了这一成果。
Title: Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior
Author: Nick T.M. Robinson, Lucie A.L. Descamps, Lloyd E. Russell, Moritz O. Buchholz, Brendan A. Bicknell, Georgy K. Antonov, Joanna Y.N. Lau, Rebecca Nutbrown, Christoph Schmidt-Hieber, Michael Husser
Issue&Volume: 2020-11-06
Abstract: The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment and have been proposed to form the neural basis of a cognitive map of space that supports these mnemonic functions. However, the direct influence of place cell activity on spatial navigation behavior has not yet been demonstrated. Using an ‘all-optical’ combination of simultaneous two-photon calcium imaging and two-photon optogenetics, we identified and selectively activated place cells that encoded behaviorally relevant locations in a virtual reality environment. Targeted stimulation of a small number of place cells was sufficient to bias the behavior of animals during a spatial memory task, providing causal evidence that hippocampal place cells actively support spatial navigation and memory.
DOI: 10.1016/j.cell.2020.09.061
Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31302-7