美国华盛顿大学Marion Pepper研究小组发现，轻度COVID-19感染可产生持久的SARS-CoV-2特异性免疫记忆。该研究于2020年11月23日在线发表于国际学术期刊《细胞》。

Title: Functional SARS-CoV-2-specific immune memory persists after mild COVID-19

Author: Lauren B. Rodda, Jason Netland, Laila Shehata, Kurt B. Pruner, Peter A. Morawski, Christopher D. Thouvenel, Kennidy K. Takehara, Julie Eggenberger, Emily A. Hemann, Hayley R. Waterman, Mitchell L. Fahning, Yu Chen, Malika Hale, Jennifer Rathe, Caleb Stokes, Samuel Wrenn, Brooke Fiala, Lauren Carter, Jessica A. Hamerman, Neil P. King, Michael Gale, Daniel J. Campbell, David J. Rawlings, Marion Pepper

Issue&Volume: 2020-11-23

Abstract: The SARS-CoV-2 virus is causing a global pandemic and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity. We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine if they develop and sustain multifaceted SARS-CoV-2-specific immunological memory. Recovered individuals developed SARS-CoV-2-specific IgG antibodies, neutralizing plasma, memory B and memory T cells that persisted for at least three months. Our data further reveal that SARS-CoV-2-specific IgG memory B cells increased over time. Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounter, while memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies. Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.

DOI: 10.1016/j.cell.2020.11.029

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31565-8