美国加州大学圣芭芭拉分校Denise J. Montell研究组发现，组织形貌引导果蝇边缘细胞的迁移。该研究于2020年11月20日发表于国际一流学术期刊《科学》。

Title: Tissue topography steers migrating Drosophila border cells

Author: Wei Dai, Xiaoran Guo, Yuansheng Cao, James A. Mondo, Joseph P. Campanale, Brandon J. Montell, Haley Burrous, Sebastian Streichan, Nir Gov, Wouter-Jan Rappel, Denise J. Montell

Issue&Volume: 2020/11/20

Abstract: Moving cells can sense and respond to physical features of the microenvironment; however, in vivo, the significance of tissue topography is mostly unknown. Here, we used Drosophila border cells, an established model for in vivo cell migration, to study how chemical and physical information influences path selection. Although chemical cues were thought to be sufficient, live imaging, genetics, modeling, and simulations show that microtopography is also important. Chemoattractants promote predominantly posterior movement, whereas tissue architecture presents orthogonal information, a path of least resistance concentrated near the center of the egg chamber. E-cadherin supplies a permissive haptotactic cue. Our results provide insight into how cells integrate and prioritize topographical, adhesive, and chemoattractant cues to choose one path among many.

DOI: 10.1126/science.aaz4741

Source: https://science.sciencemag.org/content/370/6519/987