美国福瑞德·哈金森癌症研究中心Kevin J. Cheung团队发现，纳米管腔信号可调节肿瘤集体转移。这一研究成果于2020年10月1日在线发表在国际学术期刊《细胞》上。

Title: Regulation of Collective Metastasis by Nanolumenal Signaling

Author: Emma D. Wrenn, Ami Yamamoto, Breanna M. Moore, Yin Huang, Margaux McBirney, Aaron J. Thomas, Erin Greenwood, Yuri F. Rabena, Habib Rahbar, Savannah C. Partridge, Kevin J. Cheung

Issue&Volume: 2020-10-1

Abstract: Collective metastasis is defined as the cohesive migration and metastasis of multicellulartumor cell clusters. Disrupting various cell adhesion genes markedly reduces clusterformation and colonization efficiency, yet the downstream signals transmitted by clusteringremain largely unknown. Here, we use mouse and human breast cancer models to identifya collective signal generated by tumor cell clusters supporting metastatic colonization.We show that tumor cell clusters produce the growth factor epigen and concentrateit within nanolumina—intercellular compartments sealed by cell-cell junctions andlined with microvilli-like protrusions. Epigen knockdown profoundly reduces metastaticoutgrowth and switches clusters from a proliferative to a collective migratory state.Tumor cell clusters from basal-like 2, but not mesenchymal-like, triple-negative breastcancer cell lines have increased epigen expression, sealed nanolumina, and impairedoutgrowth upon nanolumenal junction disruption. We propose that nanolumenal signalingcould offer a therapeutic target for aggressive metastatic breast cancers.

DOI: 10.1016/j.cell.2020.08.045

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31087-4