美国斯坦福大学Scott D. Boyd、杜克大学医学院Barton F. Haynes等研究人员合作发现,异常的B细胞库选择与HIV中和抗体广度有关。该研究于2020年1月20日在线发表于国际一流学术期刊《自然—免疫学》。
Title: Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth
Author: Krishna M. Roskin, Katherine J. L. Jackson, Ji-Yeun Lee, Ramona A. Hoh, Shilpa A. Joshi, Kwan-Ki Hwang, Mattia Bonsignori, Isabela Pedroza-Pacheco, Hua-Xin Liao, M. Anthony Moody, Andrew Z. Fire, Persephone Borrow, Barton F. Haynes, Scott D. Boyd
Issue&Volume: 2020-01-20
Abstract: A goal of HIV vaccine development is to elicit antibodies with neutralizing breadth. Broadly neutralizing antibodies (bNAbs) to HIV often have unusual sequences with long heavy-chain complementarity-determining region loops, high somatic mutation rates and polyreactivity. A subset of HIV-infected individuals develops such antibodies, but it is unclear whether this reflects systematic differences in their antibody repertoires or is a consequence of rare stochastic events involving individual clones. We sequenced antibody heavy-chain repertoires in a large cohort of HIV-infected individuals with bNAb responses or no neutralization breadth and uninfected controls, identifying consistent features of bNAb repertoires, encompassing thousands of B cell clones per individual, with correlated T cell phenotypes. These repertoire features were not observed during chronic cytomegalovirus infection in an independent cohort. Our data indicate that the development of numerous B cell lineages with antibody features associated with autoreactivity may be a key aspect in the development of HIV neutralizing antibody breadth.
DOI: 10.1038/s41590-019-0581-0
Source: https://www.nature.com/articles/s41590-019-0581-0
Nature Immunology:《自然—免疫学》,创刊于2000年。隶属于施普林格·自然出版集团,最新IF:23.53
官方网址:https://www.nature.com/ni/
投稿链接:https://mts-ni.nature.com/cgi-bin/main.plex