美国斯坦福大学Scott D. Boyd、杜克大学医学院Barton F. Haynes等研究人员合作发现，异常的B细胞库选择与HIV中和抗体广度有关。该研究于2020年1月20日在线发表于国际一流学术期刊《自然—免疫学》。
Title: Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth
Author: Krishna M. Roskin, Katherine J. L. Jackson, Ji-Yeun Lee, Ramona A. Hoh, Shilpa A. Joshi, Kwan-Ki Hwang, Mattia Bonsignori, Isabela Pedroza-Pacheco, Hua-Xin Liao, M. Anthony Moody, Andrew Z. Fire, Persephone Borrow, Barton F. Haynes, Scott D. Boyd
Abstract: A goal of HIV vaccine development is to elicit antibodies with neutralizing breadth. Broadly neutralizing antibodies (bNAbs) to HIV often have unusual sequences with long heavy-chain complementarity-determining region loops, high somatic mutation rates and polyreactivity. A subset of HIV-infected individuals develops such antibodies, but it is unclear whether this reflects systematic differences in their antibody repertoires or is a consequence of rare stochastic events involving individual clones. We sequenced antibody heavy-chain repertoires in a large cohort of HIV-infected individuals with bNAb responses or no neutralization breadth and uninfected controls, identifying consistent features of bNAb repertoires, encompassing thousands of B cell clones per individual, with correlated T cell phenotypes. These repertoire features were not observed during chronic cytomegalovirus infection in an independent cohort. Our data indicate that the development of numerous B cell lineages with antibody features associated with autoreactivity may be a key aspect in the development of HIV neutralizing antibody breadth.