美国耶鲁大学医学院Yibing Qyang团队取得一项成果,他们利用人类iPSC产生了具有优良机械强度的组织工程化血管移植物。2020年1月16日,《细胞—干细胞》杂志在线发表了这项成果。
Title: Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs
Author: Jiesi Luo, Lingfeng Qin, Liping Zhao, Liqiong Gui, Matthew W. Ellis, Yan Huang, Mehmet H. Kural, J. Alexander Clark, Shun Ono, Juan Wang, Yifan Yuan, Shang-Min Zhang, Xiaoqiang Cong, Guangxin Li, Muhammad Riaz, Colleen Lopez, Akitsu Hotta, Stuart Campbell, George Tellides, Alan Dardik, Laura E. Niklason, Yibing Qyang
Issue&Volume: January 16, 2020
Abstract: Vascular smooth muscle cells (VSMCs) can be derived in large numbers from human inducedpluripotent stem cells (hiPSCs) for producing tissue-engineered vascular grafts (TEVGs).However, hiPSC-derived TEVGs are hampered by low mechanical strength and significantradial dilation after implantation. Here, we report generation of hiPSC-derived TEVGswith mechanical strength comparable to native vessels used in arterial bypass graftsby utilizing biodegradable scaffolds, incremental pulsatile stretching, and optimalculture conditions. Following implantation into a rat aortic model, hiPSC-derivedTEVGs show excellent patency without luminal dilation and effectively maintain mechanicaland contractile function. This study provides a foundation for future production ofnon-immunogenic, cellularized hiPSC-derived TEVGs composed of allogenic vascular cells,potentially serving needs to a considerable number of patients whose dysfunctionalvascular cells preclude TEVG generation via other methods.
DOI: 10.1016/j.stem.2019.12.012
Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30570-3
Cell Stem Cell:《细胞—干细胞》,创刊于2007年。隶属于细胞出版社,最新IF:21.464
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