生殖器区域使用爽身粉与卵巢癌之间的关系，这一成果由美国国家癌症研究所Nicolas Wentzensen联合美国国立环境健康科学研究所Katie M. O’Brien研究团队取得。相关论文发表在2020年1月7日出版的《美国医学会杂志》上。

目前，在生殖器区域使用爽身粉与卵巢癌之间的关系尚未确定。病历对照研究中的阳性相关性尚未在队列研究中证实。

为了确认在生殖器区域使用爽身粉与卵巢癌发病率之间的关系，1976-2017年，研究组对美国4个大型前瞻性队列中的女性进行了随访分析，共招募了252745名女性，基线中位年龄为57岁。其中38%的女性会在生殖器区域使用爽身粉，10%的女性长期使用（超过20年），22%的女性频繁使用（每周至少一次）。

在平均11.2年（共380万人年）的随访中，共有2168名女性患上卵巢癌（每10万人年58例）。生殖器区域使用爽身粉的女性卵巢癌发病率为每10万人年61例，而生殖器区域从未使用过爽身粉的女性为每10万人年55例。与生殖器区域从未使用爽身粉相比，频繁使用的估计风险比为1.09，长期使用为1.01。

对10个变量进行亚组分析，其异质性检验均无统计学意义。在生殖道通畅的女性中，生殖器区域使用爽身粉与卵巢癌风险之间的关联性估计风险比为1.13，与生殖道不通畅的女性相比，交互P值为0.15。

总之，生殖器区域使用爽身粉与卵巢癌发病率之间并无统计学相关性。然而，这项研究尚无力确定卵巢癌风险的小幅增加。

附：英文原文

Title: Association of Powder Use in the Genital Area With Risk of Ovarian Cancer

Author: Katie M. O’Brien, Shelley S. Tworoger, Holly R. Harris, Garnet L. Anderson, Clarice R. Weinberg, Britton Trabert, Andrew M. Kaunitz, Aimee A. D’Aloisio, Dale P. Sandler, Nicolas Wentzensen

Issue&Volume: 2020/01/07

Abstract: 

Importance  The relationship between use of powder in the genital area and ovarian cancer is not established. Positive associations reported in case-control studies have not been confirmed in cohort studies.

Objective  To estimate the association between use of powder in the genital area and ovarian cancer using prospective observational data.

Design, Setting, and Participants  Data were pooled from 4 large, US-based cohorts: Nurses’ Health Study (enrollment 1976; follow-up 1982-2016; n = 81?869), Nurses’ Health Study II (enrollment 1989; follow-up 2013-2017; n = 61?261), Sister Study (enrollment 2003-2009; follow-up 2003-2017; n = 40?647), and Women’s Health Initiative Observational Study (enrollment 1993-1998; follow-up 1993-2017; n = 73?267).

Exposures  Ever, long-term (≥20 years), and frequent (≥1/week) use of powder in the genital area.

Main Outcomes and Measures  The primary analysis examined the association between ever use of powder in the genital area and self-reported incident ovarian cancer. Covariate-adjusted hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models.

Results  The pooled sample included 252?745 women (median age at baseline, 57 years) with 38% self-reporting use of powder in the genital area. Ten percent reported long-term use, and 22% reported frequent use. During a median of 11.2 years of follow-up (3.8 million person-years at risk), 2168 women developed ovarian cancer (58 cases/100?000 person-years). Ovarian cancer incidence was 61 cases/100?000 person-years among ever users and 55 cases/100?000 person-years among never users (estimated risk difference at age 70 years, 0.09% [95% CI, −0.02% to 0.19%]; estimated HR, 1.08 [95% CI, 0.99 to 1.17]). The estimated HR for frequent vs never use was 1.09 (95% CI, 0.97 to 1.23) and for long-term vs never use, the HR was 1.01 (95% CI, 0.82 to 1.25). Subgroup analyses were conducted for 10 variables; the tests for heterogeneity were not statistically significant for any of these comparisons. While the estimated HR for the association between ever use of powder in the genital area and ovarian cancer risk among women with a patent reproductive tract was 1.13 (95% CI, 1.01 to 1.26), the P value for interaction comparing women with vs without patent reproductive tracts was .15.

Conclusions and Relevance  In this analysis of pooled data from women in 4 US cohorts, there was not a statistically significant association between use of powder in the genital area and incident ovarian cancer. However, the study may have been underpowered to identify a small increase in risk.

DOI: 10.1001/jama.2019.20079

Source: https://jamanetwork.com/journals/jama/article-abstract/2758452