法国勃艮第特许权伯爵大学Judith Burstin研究组近日取得一项新成果，他们绘制了首个豌豆的参考基因组并为豆科植物的基因组进化提供了新见解。相关论文2019年9月发表在国际学术期刊《自然—遗传学》上。

研究人员报道了第一个注释的豌豆染色体水平参考基因组，豌豆是孟德尔使用的遗传模型。 系统发育学和古生物基因组学显示了豆科植物的基因组重排，并表明重复元件在豌豆基因组进化中的主要作用。与其他测序的豆科基因组相比，豌豆基因组显示出强烈的基因动态，当Fabeae从其姐妹部落分离时，很可能与基因组大小扩增有关。在豌豆进化过程中，易位和转座在不同谱系中发生差异。该参考序列将加速人们对农艺学重要性状的分子基础的理解，并促进作物改良。

附：英文原文

Title: A reference genome for pea provides insight into legume genome evolution

Author: Jonathan Kreplak, Mohammed-Amin Madoui, Petr Cpal, Petr Novk, Karine Labadie, Grgoire Aubert, Philipp E. Bayer, Krishna K. Gali, Robert A. Syme, Dorrie Main, Anthony Klein, Aurlie Brard, Iva Vrbov, Cyril Fournier, Leo dAgata, Caroline Belser, Wahiba Berrabah, Helena Toegelov, Zbynk Milec, Jan Vrna, HueyTyng Lee, Ayit Kougbeadjo, Morgane Trzol, Ccile Huneau, Chala J. Turo, Nacer Mohellibi, Pavel Neumann, Matthieu Falque, Karine Gallardo, Rebecca McGee, Bunyamin Taran, Abdelhafid Bendahmane, Jean-Marc Aury, Jacqueline Batley, Marie-Christine Le Paslier, Noel Ellis, Thomas D. Warkentin, Clarice J. Coyne, Jrome Salse, David Edwards, Judith Lichtenzveig, Ji Macas, Jaroslav Doleel, Patrick Wincker, Judith Burstin

Issue&Volume: Volume 51 Issue 9

Abstract: We report the first annotated chromosome-level reference genome assembly for pea, Gregor Mendels original genetic model. Phylogenetics and paleogenomics show genomic rearrangements across legumes and suggest a major role for repetitive elements in pea genome evolution. Compared to other sequenced Leguminosae genomes, the pea genome shows intense gene dynamics, most likely associated with genome size expansion when the Fabeae diverged from its sister tribes. During Pisum evolution, translocation and transposition differentially occurred across lineages. This reference sequence will accelerate our understanding of the molecular basis of agronomically important traits and support crop improvement.

DOI: 10.1038/s41588-019-0480-1

Source: https://www.nature.com/articles/s41588-019-0480-1