美国希望之城综合癌症中心Peter P. Lee研究组的一项最新发现，揭示了血液和瘤内调节性T细胞的活性在乳腺癌复发中的作用。2019年9月，国际知名学术期刊《自然—免疫学》发表了这一成果。

研究人员发现，外周血CD45RA-FOXP3^hi 调节性T细胞（T_reg II细胞）在表型上最接近肿瘤内T_reg细胞，包括它们的CCR8表达。对T细胞抗原受体库的分析进一步支持了肿瘤内T_reg细胞可能主要来源于外周血T_reg II细胞的假设。此外，外周血T_reg II细胞对免疫抑制性1型辅助T细胞（T_H1）和2型辅助T细胞（T_H2）细胞因子的信号响应性反映了肿瘤内免疫抑制潜能，并预测了两个独立的乳腺癌患者群体的未来复发。

总之，这些研究结果为外周血T_reg细胞和肿瘤内T_reg细胞之间的关系提供了重要的见解，并突出了细胞因子信号反应作为肿瘤内免疫抑制潜力和临床结果的关键决定因素。

研究人员表示，调节性T（T_reg）细胞在免疫抑制性肿瘤微环境的发展中起主要作用。肿瘤内T_reg细胞的起源及其与外周血T_reg细胞的关系尚不清楚。T_reg细胞由至少三个功能不同的亚群组成。

附：英文原文

Title: Connecting blood and intratumoral T reg cell activity in predicting future relapse in breast cancer

Author: Lei Wang, Diana L. Simons, Xuyang Lu, Travis Y. Tu, Shawn Solomon, Roger Wang, Anthony Rosario, Christian Avalos, Daniel Schmolze, John Yim, James Waisman, Peter P. Lee

Issue&Volume: Volume 20 Issue 9

Abstract: Regulatory T (Treg) cells play a major role in the development of an immunosuppressive tumor microenvironment. The origin of intratumoral Treg cells and their relationship with peripheral blood Treg cells remain unclear. Treg cells consist of at least three functionally distinct subpopulations. Here we show that peripheral blood CD45RA−FOXP3hi Treg cells (Treg II cells) are phenotypically closest to intratumoral Treg cells, including in their expression of CCR8. Analyses of T cell antigen receptor repertoires further support the hypothesis that intratumoral Treg cells may originate primarily from peripheral blood Treg II cells. Moreover, the signaling responsiveness of peripheral blood Treg II cells to immunosuppressive, T helper type 1 (TH1) and T helper type 2 (TH2) cytokines reflects intratumoral immunosuppressive potential, and predicts future relapse in two independent cohorts of patients with breast cancer. Together, our findings give important insights into the relationship between peripheral blood Treg cells and intratumoral Treg cells, and highlight cytokine signaling responsiveness as a key determinant of intratumoral immunosuppressive potential and clinical outcome.

DOI: 10.1038/s41590-019-0429-7

Source:https://www.nature.com/articles/s41590-019-0429-7