魏茨曼科学研究所Gad Asher团队对运动能力日变化的生理和分子进行了分析。相关论文于2019年发表在《细胞—代谢》上。

该课题组研究人员发现，小鼠和人类在活动阶段的早期和晚期都表现出日间运动能力的差异。小鼠白天的变化依赖于运动强度，并依赖于生理时钟蛋白PER1/2。骨骼肌的高通量基因表达和代谢谱分析揭示了代谢途径以白天依赖的方式在运动时被不停的激活。值得注意的是，研究小组发现ZMP，一种内源性AMPK激活剂，是由运动诱导的，以一种时间依赖的方式调节糖酵解和脂肪酸氧化途径的关键步骤，并可能提高运动能力。总的来说，小组认为一天中的时间是锻炼能力和相关代谢途径的主要调节因素。

据悉，身体的表现依赖于无数反应的协调行动，其中许多都在昼夜节律的控制之下。然而，在分子水平上对运动成绩的时间依赖效应知之甚少。

附：英文原文

Title: Physiological and Molecular Dissection of Daily Variance in Exercise Capacity

Author: Saar Ezagouri, Ziv Zwighaft, Jonathan Sobel, Sébastien Baillieul, Stéphane Doutreleau, Benjamin Ladeuix, Marina Golik, Samuel Verges, Gad Asher

Issue&Volume: JULY 02, 2019 Vol30 Issue1

Abstract: Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity between the early and late part of their active phase. The daytime variance in mice was dependent on exercise intensity and relied on the circadian clock proteins PER1/2. High-throughput gene expression and metabolic profiling of skeletal muscle revealed metabolic pathways that are differently activated upon exercise in a daytime-dependent manner. Remarkably, we discovered that ZMP, an endogenous AMPK activator, is induced by exercise in a time-dependent manner to regulate key steps in glycolytic and fatty acid oxidation pathways and potentially enhance exercise capacity. Overall, we propose that time of day is a major modifier of exercise capacity and associated metabolic pathways.

DOI: https://doi.org/10.1016/j.cmet.2019.03.012

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30141-X