来源:Communications Biology 发布时间:2019/3/19 12:42:01
选择字号:
通过分析tRNA和翻译因子的表达来研究人类癌症中的翻译调控

论文标题:Global analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers

期刊:Communications Biology

作者:Zhao Zhang, Youqiong Ye, Jing Gong, Hang Ruan, Chun-Jie Liu, Yu Xiang, Chunyan Cai, An-Yuan Guo, Jiqiang Ling, Lixia Diao, John N. Weinstein, Leng Han

发表时间:2018/12/21

数字识别码: 10.1038/s42003-018-0239-8

原文链接:http://t.cn/EMgWivJ

蛋白质翻译系统包括转运RNA(tRNA)和相关的几类酶,它在细胞增殖调控中起到了重要作用。而翻译调节异常则会引起癌症的发生。然而,在癌症中翻译系统到底发生了怎样的变化,目前我们了解得还不甚清晰。

来自德克萨斯大学的Leng Han团队近期在 Communications Biology发表的研究Global analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers中对于参与了翻译调控的tRNA和三类酶进行了全局分析,他们的团队分析了来自肿瘤基因组计划数据库(The Cancer Genome Atlas)中约一万名癌症患者,涵盖31种癌症类型的数据。

通过分析基因层面、密码子层面和氨基酸层面的tRNA表达水平,作者发现了tRNA表达的不均衡变化,这一现象很可能是由于解码不同密码子的tRNA分布不均导致的。研究发现,如果过表达识别密码子的tRNA具有较低的观察数-预期数比率,或许能够克服肿瘤发生过程中的翻译瓶颈。研究还观察到了tRNA修饰酶、氨酰tRNA合成酶、翻译因子的整体过表达和扩增。这些现象可能与tRNA过表达存在协同作用,在多种类型的癌症中共同激活翻译系统。

摘要:The protein translational system, including transfer RNAs (tRNAs) and several categories of enzymes, plays a key role in regulating cell proliferation. Translation dysregulation also contributes to cancer development, though relatively little is known about the changes that occur to the translational system in cancer. Here, we present global analyses of tRNAs and three categories of enzymes involved in translational regulation in ~10,000 cancer patients across 31 cancer types from The Cancer Genome Atlas. By analyzing the expression levels of tRNAs at the gene, codon, and amino acid levels, we identified unequal alterations in tRNA expression, likely due to the uneven distribution of tRNAs decoding different codons. We find that overexpression of tRNAs recognizing codons with a low observed-over-expected ratio may overcome the translational bottleneck in tumorigenesis. We further observed overall overexpression and amplification of tRNA modification enzymes, aminoacyl-tRNA synthetases, and translation factors, which may play synergistic roles with overexpression of tRNAs to activate the translational systems across multiple cancer types.

阅读论文全文请访问:http://t.cn/EMgWivJ

期刊介绍:Communications Biology(https://www.nature.com/commsbio/) is an open access journal from Nature Research publishing high-quality research, reviews and commentary in all areas of the biological sciences. Research papers published by the journal represent significant advances bringing new biological insight to a specialized area of research.

(来源:科学网)

 
 
 
特别声明:本文转载仅仅是出于传播信息的需要,并不意味着代表本网站观点或证实其内容的真实性;如其他媒体、网站或个人从本网站转载使用,须保留本网站注明的“来源”,并自负版权等法律责任;作者如果不希望被转载或者联系转载稿费等事宜,请与我们接洽。
 
 打印  发E-mail给: 
    
 
以下评论只代表网友个人观点,不代表科学网观点。
 
相关新闻 相关论文

图片新闻
史上最大水下火山爆发 我国系留浮空器创高空探测世界纪录
“木联网”来了! 新加坡“假新闻”法引发强烈抗议
>>更多
 
一周新闻排行 一周新闻评论排行
 
编辑部推荐博文