美国加州大学旧金山分校Li Gan研究组发现小胶质细胞microRNAs介导对tau病理的性别特异性反应。该研究2019年12月23日发表于国际学术期刊《自然—神经科学》。

在小鼠中，小胶质细胞microRNA的表达在雄性和雌性中有所不同，并且microRNA的缺失会导致小胶质细胞转录组和tau病理学中的性别特异性变化。这些研究表明，小胶质细胞microRNA以性别特异性的方式影响tau致病机制。

据了解，性别是神经系统疾病预后的关键调节因素。小胶质细胞与神经系统疾病有关，并受microRNA调控，但小胶质细胞microRNA是否对疾病具有性别特异性影响尚不清楚。

附：英文原文

Title: Microglial microRNAs mediate sex-specific responses to tau pathology

Author: Lay Kodama, Elmer Guzman, Jon I. Etchegaray, Yaqiao Li, Faten A. Sayed, Lu Zhou, Yungui Zhou, Lihong Zhan, David Le, Joe C. Udeochu, Claire D. Clelland, Zuolin Cheng, Guoqiang Yu, Qingyun Li, Kenneth S. Kosik, Li Gan

Issue&Volume: 2019-12-23

Abstract: Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.

DOI: 10.1038/s41593-019-0560-7

Source: https://www.nature.com/articles/s41593-019-0560-7