英国纽卡斯尔大学Roy Taylor和Ahmad Al-Mrabeh合作探究了2型糖尿病患者减肥后，其肝脂蛋白输出与糖尿病缓解的关系。该项研究成果在线发表在2019年12月19日的《细胞—代谢》上。

在糖尿病缓解临床试验亚组中，研究人员发现肝VLDL1-甘油三酯的产率和VLDL1-棕榈酸含量对胰腺内脂肪变化和恢复第一阶段胰岛素反应的关系。2型糖尿病患者体重减轻后，其肝脏脂肪、VLDL1-甘油三酯的产量和胰内脂肪减少，并可维持24个月。第一阶段胰岛素反应增加仅发生在稳定缓解的糖尿病患者中。与24个月缓解的患者相比，初次缓解后复发的患者其VLDL1-甘油三酯和VLDL1-棕榈酸的含量增加更快，胰腺内脂肪重新积累，并在24个月时失去第一阶段反应。因此，研究人员在时间上建立了VLDL1-甘油三酯产生、棕榈酸通量、胰内脂肪和β细胞功能之间的联系。该研究揭示与体重有关的脂肪代谢紊乱似乎会推动2型糖尿病的发展和逆转。

据悉，目前尚不清楚肝脂蛋白代谢在食源缓解的2型糖尿病患者中所起的作用。

附：英文原文

Title: Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss

Author: Ahmad Al-Mrabeh, Sviatlana V. Zhyzhneuskaya, Carl Peters, Alison C. Barnes, Shaden Melhem, Aaron Jesuthasan, Benjamin Aribisala, Kieren G. Hollingsworth, Georg Lietz, John C. Mathers, Naveed Sattar, Michael E.J. Lean, Roy Taylor

Issue&Volume: December 19, 2019

Abstract: The role of hepatic lipoprotein metabolism in diet-induced remission of type 2 diabetesis currently unclear. Here, we determined the contributions of hepatic VLDL1-triglycerideproduction rate and VLDL1-palmitic acid content to changes in intra-pancreatic fatand return of first phase insulin response in a subgroup of the Diabetes RemissionClinical Trial. Liver fat, VLDL1-triglyceride production, and intra-pancreatic fatdecreased after weight loss and remained normalized after 24 months of remission.First-phase insulin response remained increased only in those maintaining diabetesremission. Compared with those in remission at 24 months, individuals who relapsedafter initial remission had a greater rise in the content of VLDL1-triglyceride andVLDL1-palmitic acid, re-accumulated intra-pancreatic fat, and lost first-phase responseby 24 months. Thus, we observed temporal relationships between VLDL1-triglycerideproduction, hepatic palmitic acid flux, intra-pancreatic fat, and β-cell function.Weight-related disordered fat metabolism appears to drive development and reversalof type 2 diabetes.

DOI: 10.1016/j.cmet.2019.11.018

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30662-X