亮氨酸tRNA合成酶1（LARS1）以葡萄糖依赖性方式调控亮氨酸代谢，这一成果由韩国国立首尔大学Sunghoon Kim、Jong Hyun Kim等研究人员合作完成。2019年11月28日，国际知名学术期刊《科学》在线发表了这一成果。

研究人员为LARS1在葡萄糖依赖的亮氨酸使用控制中的作用提供了证据。在葡萄糖饥饿时，ULK1（Unc-51 like autophagy activating kinase 1）在亮氨酸结合的关键残基处将LARS1磷酸化。磷酸化的LARS1表现出亮氨酸结合减少，这可能抑制蛋白质合成并帮助节省能量。不用于合成代谢过程的亮氨酸可能可用于分解代谢途径以产生能量。

LARS1介导的亮氨酸利用率变化可能有助于促进缺乏葡萄糖的细胞存活。因此，取决于葡萄糖的可用性，LARS1可以帮助调节亮氨酸是否用于蛋白质合成或能量产生。

据悉，尽管葡萄糖和氨基酸对于能量代谢很重要，但对两种营养素之间的相互作用却知之甚少。

附：英文原文

Title: Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1

Author: Ina Yoon, Miso Nam, Hoi Kyoung Kim, Hee-Sun Moon, Sungmin Kim, Jayun Jang, Ji Ae Song, Seung Jae Jeong, Sang Bum Kim, Seongmin Cho, YounHa Kim, Jihye Lee, Won Suk Yang, Hee Chan Yoo, Kibum Kim, Min-Sun Kim, Aerin Yang, Kyukwang Cho, Hee-Sung Park, Geum-Sook Hwang, Kwang Yeon Hwang, Jung Min Han, Jong Hyun Kim, Sunghoon Kim

Issue&Volume: 2020/11/28

Abstract: AbstractDespite the importance of glucose and amino acids for energy metabolism, interactions between the two nutrients are not well understood. We provide evidence for a role of leucyl-tRNA synthetase 1 (LARS1) in glucose-dependent control of leucine usage. Upon glucose starvation, LARS1 was phosphorylated by Unc-51 like autophagy activating kinase 1 (ULK1) at the residues crucial for leucine-binding. The phosphorylated LARS1 showed decreased leucine-binding, which may inhibit protein synthesis and help save energy. Leucine, not used to anabolic process, may be available to catabolic pathway for energy generation. The LARS1-mediated changes in leucine utilization might help support cell survival deprived of glucose. Thus, dependent on the availability of glucose, LARS1 may help regulate whether leucine is used for protein synthesis or energy production.

DOI: 10.1126/science.aau2753

Source: https://science.sciencemag.org/content/early/2019/11/25/science.aau2753