美国匹兹堡大学Sarah L. Gaffen和克利夫兰诊所Xiaoxia Li合作介绍了IL-17受体信号转导途径及其对疾病的影响。相关论文11月19日在线发表在国际学术期刊《自然—免疫学》上。

IL-17是常见的促炎细胞因子，对包括宿主防御、组织修复、炎性疾病的发病机制和癌症的进展等过程至关重要。出人意料的是，与它在体内发挥的深远作用相反，IL-17在细胞培养中却只表现出中等活性，这表明IL-17信号传导的分子机制存在重要的知识空缺。

越来越多的研究揭示了IL-17途径的复杂性，这有助于解释其高效的体内活性。新型mRNA稳定剂和受体指导的mRNA代谢的发现，为理解IL-17与其他功能性刺激相协调驱动炎症（无论是有益的还是破坏性的）发生提供了新思路。

特定细胞中IL-17与生长受体信号途径结合，这为理解IL-17在组织修复以及如何促进癌症细胞的有丝分裂提供了新的认识。该综述总结了IL-17信号转导途径的新进展及其病理生理意义。

附：英文原文

Title: IL-17 receptor–based signaling and implications for disease

Author: Xiaoxia Li, Rami Bechara, Junjie Zhao, Mandy J. McGeachy, Sarah L. Gaffen

Issue&Volume: 2019-11-19

Abstract: IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes, including host defense, tissue repair, the pathogenesis of inflammatory disease and the progression of cancer. In contrast to its profound impact in vivo, IL-17 exhibits surprisingly moderate activity in cell-culture models, which presents a major knowledge gap about the molecular mechanisms of IL-17 signaling. Emerging studies are revealing a new dimension of complexity in the IL-17 pathway that may help explain its potent and diverse in vivo functions. Discoveries of new mRNA stabilizers and receptor-directed mRNA metabolism have provided insights into the means by which IL-17 cooperates functionally with other stimuli in driving inflammation, whether beneficial or destructive. The integration of IL-17 with growth-receptor signaling in specific cell types offers new understanding of the mitogenic effect of IL-17 on tissue repair and cancer. This Review summarizes new developments in IL-17 signaling and their pathophysiological implications.

DOI: 10.1038/s41590-019-0514-y

Source: https://www.nature.com/articles/s41590-019-0514-y