美国贝纳罗亚研究所Steven F. Ziegler等研究人员，综述了胸腺基质淋巴细胞生成素（TSLP）从过敏到癌症的功能。相关论文11月19日在线发表在《自然—免疫学》上。

已有研究证明，细胞因子TSLP是维持免疫稳态和调节粘膜屏障炎症反应的关键因素。 尽管已有广泛研究证明TSLP在2型免疫应答中的作用，但最近的研究发现TSLP在炎症性疾病和癌症中也发挥功能。

在本综述中，研究人员重点介绍了关于TSLP生物功能的最新进展，以及用于治疗多种炎性疾病的新兴抗TSLP药物的临床实验结果。

附：英文原文

Title: TSLP: from allergy to cancer

Author: Jonathan Corren, Steven F. Ziegler

Issue&Volume: 2019-11-19

Abstract: The cytokine TSLP has been shown to be a key factor in maintaining immune homeostasis and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 immune responses has been investigated extensively, recent studies have found an expanding role for TSLP in inflammatory diseases and cancer. In this Review, we will highlight major recent advances in TSLP biology, along with results from emerging clinical trials of anti-TSLP agents used for the treatment of a variety of inflammatory conditions.

DOI: 10.1038/s41590-019-0524-9

Source: https://www.nature.com/articles/s41590-019-0524-9