RBPJ依赖性Notch信号调控T细胞发育
作者：小柯机器人 发布时间：2019/10/22 16:14:01
加拿大多伦多大学Juan Carlos Zúñiga-Pflücker小组近期发现，RBPJ依赖性Notch信号在胸腺的祖细胞亚型中启动T细胞发育程序。相关论文2019年10月21日在线发表于《自然—免疫学》。
研究人员建立了一个Rbpj诱导系统，该系统可以在时间和组织方面控制所有造血细胞对Notch的反应。使用该系统，研究人员发现在胸腺的T细胞祖细胞早期之前需要Notch信号传导。骨髓中淋巴样多能祖细胞经历了带有Rbpj诱导的Notch信号传导，该信号抑制了胸腺祖细胞向骨髓谱系的发育。
因此，这些结果表明，T细胞分化的起始发生在胸腺发生前，而Notch在此事件中起着重要作用。
据了解，T细胞分化和决定需要Notch信号。尽管在胸腺内T细胞发育过程中对Notch信号的需求是已知的，但仍不清楚在胸腺微环境中是否可发生T细胞活化的起始，以及RBPJ依赖性Notch信号在此事件中是否起作用。
附：英文原文
Title:RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors
Author:Edward L. Y. Chen, Patrycja K. Thompson & Juan Carlos Zúñiga-Pflücker
Issue&Volume:21 October 2019
Abstract:
T cell specification and commitment require Notch signaling. Although the requirement for Notch signaling during intrathymic T cell development is known, it is still unclear whether the onset of T cell priming can occur in a prethymic niche and whether RBPJ-dependent Notch signaling has a role during this event. Here, we established an Rbpj-inducible system that allowed temporal and tissue-specific control of the responsiveness to Notch in all hematopoietic cells. Using this system, we found that Notch signaling was required before the early T cell progenitor stage in the thymus. Lymphoid-primed multipotent progenitors in the bone marrow underwent Notch signaling with Rbpj induction, which inhibited development towards the myeloid lineage in thymus-seeding progenitors. Thus, our results indicated that the onset of T cell differentiation occurred in a prethymic setting, and that Notch played an important role during this event.
DOI:10.1038/s41590-019-0518-7
期刊信息
Nature Immunology：《自然—免疫学》，创刊于2000年。隶属于施普林格·自然出版集团，最新IF：23.53
官方网址：https://www.nature.com/ni/
投稿链接：https://mts-ni.nature.com/cgi-bin/main.plex