直播时间：2024年5月7日（周二）20:00-22:00

 

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北京时间5月7日晚八点，iCANX Youth Talks第五十四期邀请到了南方科技大学刘吉，密歇根州立大学刘心悦，南方科技大学肖凯三位教授主讲，澳门大学贾艳伟作为主持人，中国科学技术大学王柳，中国科学院纳米能源研究所唐伟担任嘉宾，期待你一起加入这场知识盛宴。

 

【嘉宾介绍】

 

 

 

 

刘吉

 

南方科技大学

 

功能水凝胶电子界面

 

【Abstract】

 

Hydrogel materials are highly similar in structure and composition to biological tissues, and are emerged as one of the most ideal materials for the bioelectronics interfacing. Traditional synthetic hydrogels exhibit low strength and are prone to brittle fracture. It remains challenge to form seamless interface between the hydrogel materials and biological tissues, due to the presence of free water at the interface, which greatly hampers their in vivo applications. To address these challenges, we have constructed a series of functional hydrogel materials and bioelectronic interfaces through multi-scale structural design and fabrication, in order to provide potential solutions to challenges in the fields of bioelectronics and tissue engineering.

 

水凝胶材料和生物组织在结构和组成上有着高度的相似性，被认为是人体组织与生物电子交互界面的最理想材料之一。传统合成水凝胶强度低，易发生脆性断裂；在潮湿的生理环境下，由于界面游离水的存在，水凝胶材料很难与生物组织形成有效的粘合界面，很大程度上限制了它们的应用。针对上述挑战，我们通过多尺度结构设计，构筑了一系列功能特异性水凝胶材料和生物电子界面，以满足不同场景的应用需求，为生物电子和组织工程等领域的挑战提供潜在的解决策略。

 

【BIOGRAPHY】

 

Dr Ji Liu is currently an Associate Professor in the Department of Mechanical and Energy Engineering, Southern University of Science and Technology (Sustech, China). He obtained his PhD from the University of Liege (Belgium) and University of Bordeaux (France) under the framework of Erasmus Mundus Joint PhD program in 2013. Prior to joining Sustech, he conducted post-doc research in the University of Cambridge, Massachusetts Institute of Technology and Harvard Medical School. His research interest includes soft material engineering, extreme mechanics, tissue engineering, flexible electronics, and has published over 50 papers in those journals like Sci. Adv., Nat. Commun., PNAS, Adv. Mater., JACS, Angew. Chem. Int. Ed. He is also the recipient of several awards, including Nano Research Young Innovators (NR45, 2023) Awards, Innovators Under 35 of China by MIT Technology Review (2020), Guangdong Pearl River Talents Program Introduces High-Level Talents (2020), Overseas High-Caliber Personnel in ShenZhen (2020), Young Investigator Award by Japan Polymer Group (2017), Marie-Curie Research Fellow (2015), etc.

 

刘吉，南方科技大学机械与能源工程系研究员，博士生导师和课题组长。刘吉博士在欧盟Erasmus Mundus联合博士奖学金的资助下，于2013年底在法国波尔多大学和比利时列日大学获得博士学位；2014-2019年先后在玛丽居里基金会和美国国防高级研究计划局等项目资助下在剑桥大学、麻省理工学院和哈佛医学院从事研究工作；2019年9月加入加入南方科技大学。刘吉博士的研究兴趣包括软材料力学，软材料加工及器件化、动态表界面、3D打印、人体技术相关的柔性电子等。先后在Sci. Adv., Nat. Commun., PNAS, Adv. Mater., JACS, Angew. Chem. Int. Ed.,等期刊上发表文章50余篇；先后获纳米研究青年科学家奖(NR45 Awards, 2023)、英国材料矿业与矿物学会会士(2021)、《麻省理工科技评论》中国区“35岁以下科技创新35人”(2020)、珠江人才引进高层次人才青年项目(2020)、深圳市海外高层次人才(2020)、日本高分子协会青年学者奖(2017)、玛丽居里学者(2015)等荣誉。

 

 

刘心悦

 

密歇根州立大学

 

设计水凝胶以调控光子和物质传输

 

【ABSTRACT】

 

The capability to manage transport processes opens a myriad of applications, such as fiber optic communication, efficient water purification, and building thermal insulation. While hydrogels have emerged as engineering materials of significant interest due to their superior mechanical compliance and water-retaining capacity, their potential in modulating light and mass transport remains largely unexplored. Our research team focuses on developing hydrogels that can precisely control light propagation and chemical diffusion. The first representative work is designing hydrogels with high transmittance and a high refractive index to minimize the photon transport loss even under dynamic conditions. Through the controlled growth of polymeric nanocrystalline domains within the hydrogels, we have fabricated hydrogel materials with optimal absorption, scattering and refractive properties and mechanical resilience. Such material innovation led to the creation of a hydrogel optical fiber with a core-cladding structure, facilitating flexible and efficient photon propagation. A notable application of this technology is the implantation of hydrogel optical fibers for optogenetic control. These fibers effectively deliver light to peripheral nerves for optogenetic control and allow for continuous stretching without impeding natural animal behaviors. The second aspect focuses on engineering the polymer network architectures in hydrogels to enhance water diffusion during swelling and sorption. This has been achieved by introducing additional polymer transition between crystalline and amorphous states to amplify enthalpic gains from polymer-solvent interactions. We demonstrated the applications of hydrogels with improved water transport including atmospheric water harvesting and super-expandable intragastric balloons. Lastly, I will discuss the ongoing project that hydrogels are engineered with high-specificity biomolecular interactions, ensuring selective permeability of them. This has significant potential in biosensing, drug delivery, and cell culture.

 

传递过程的控制在很多领域有着广泛应用，比如光纤通讯里的光子传输，以及净化水系统的离子和水分子的传递。水凝胶材料拥有卓越的机械性能和保水能力，近年来成为引人注目的工程材料；但运用水凝胶对光和物质传输进行调节的潜力仍然未被充分开发。我们研究团队专注于研究能够精确控制光传播和化学扩散的水凝胶。第一项代表性工作是设计具有高透光率和高折射率的水凝胶，来减小动态加载过程中的的光学损失。通过在水凝胶中控制聚合物纳米晶体域的生长，我们制造了具有最优吸收、散射、折射特性和机械弹性的水凝胶材料。基于这项材料创新，我们设计了核壳结构的水凝胶光纤，促进了灵活而高效的光学传输。这项技术的一个显著应用是周围神经的光遗传控制：这些水凝胶光纤能在动物体内有效地将光传递到周围神经，不会对动物的运动有额外影响。第二个工作是关于改进水凝胶中聚合物网络结构来增强其膨胀和吸附过程中的水分扩散。通过引入晶体与非晶态之间的聚合物过渡，放大了聚合物-溶剂相互作用的焓增益。通过改进水凝胶里面的分子传递，我们实现了大气水收集和可扩展的胃内气球。总的来说，我们正致力于研究水凝胶基材中的分子和光子传递过程，这些研究将在生物传感、药物传递和环境工程中发挥重要作用。

 

【BIOGRAPHY】

 

Xinyue Liu is an Assistant Professor in the Department of Chemical Engineering and Materials Science at Michigan State University. She received her Ph.D. degree in Mechanical Engineering from Massachusetts Institute of Technology in 2021, and her bachelor’s degree from Sichuan University in 2015. From 2022 to 2023, she was a postdoctoral fellow in Mechanical Engineering at Massachusetts Institute of Technology. She has published over 20 papers in numerous high-impact journals, including Nature Methods, Nature Communications, Nature Chemical Biology, Matter, Science Advances, PNAS, Advanced Materials. Her research group currently focuses on hydrogel materials and devices as the new paradigm to control mass transport and light transmission for biomedical and environmental applications. As of April 2024, her research has been cited more than 5000 times with an H-index of 55. She was awarded with Forbes Asia 30 Under 30, MRS Graduate Student Award, Chinese Government Award for Outstanding Students.

 

刘心悦，美国密歇根州立大学化工材料系助理教授。刘心悦2015年于四川大学本科毕业，此后于2021年在美国麻省理工大学获得机械工程博士学位。2022年到2023年期间，曾在美国麻省理工大学系进行博士后研究。她在一些高影响力期刊上发表20余篇论文，其中包括Nature Methods, Nature Communications, Nature Chemical Biology, Matter, Science Advances, PNAS, Advanced Materials等刊物。她的课题组正致力于研究水凝胶材料以及器件作为用于医疗、农业、环境实践的新一代技术。截止2024年4月，她的工作被引用5000 余次，H指数21。她还被授予Forbes亚洲30 Under 30奖，MRS研究生奖，中国CSC海外优秀学生奖等奖项。

 

 

肖凯

 

南方科技大学

 

神经仿生离子信息材料与器件

 

【ABSTRACT】

 

The language of intelligent life is "ions", and the language of artificial intelligence is "electrons". To build a high-throughput and low-power brain-like computing system, the "Neuro-inspired Materials and Devices Lab" conducts interdisciplinary research of ionic energy and computing materials and devices involving chemistry, materials, information, and biology, which has the potential to break through the barriers of information exchange between intelligent life and artificial intelligence. We constructed a bioinspired multi-scale ion transport system, including nanofluidic system and soft ionic conductor system, revealed the interaction law between ion transport behavior and material structure/interface, fabricated a series of ionic energy devices (e.g., ion pump/ion-electron Coulomb drag energy generator) and ionic brain-like devices (e.g., ionic memristor/ionic neuromorphic chips). We hope the energy and neuromorphic devices using "ions" as language have the potential for realizing brain-machine hybrid intelligence.

 

离子在智能生命体中至关重要，神经细胞中动作电位的产生、植物细胞光合作用、皮肤的压力感知等都和离子的定向传输密切相关。可以说，智能生命的语言是“离子”，而人工智能的语言是“电子”。因此，如何构筑基于离子传输的类脑计算器件，从而架起智能生命和仿生体系的桥梁，是我们未来面向脑-机混合智能的一个重要挑战。该研究方向是受生物蛋白质通道及其离子输运功能的启发，近年来随着纳米科学与信息技术的发展而兴起的最前沿和最活跃的课题之一。我们课题组围绕“神经仿生材料、类脑计算器件、神经调控技术”这一主题开展化学、材料、信息、生物等多学科交叉研究。通过仿生的手段构筑了一系列离子传输材料，通过调控其结构和界面性质，探究了限域空间/界面内可控离子传输的机制，实现了类脑的多种脉冲放电功能；在此基础上，基于深度神经网络（DNN）和脉冲神经网络的（SNN）的新型类脑算法，实现了低能耗、高通量的类脑计算；通过在多尺度范围内构筑基于离子传输的神经拟态器件，实现了以“离子”为语言的类脑计算器件的构筑并用于生物信号/信息调控和“人工智能-生物智能”无障碍沟通。

 

【BIOGRAPHY】

 

Dr. Kai Xiao is an associate professor at the Department of Biomedical Engineering, Southern University of Science and Technology, China. Kai Xiao received his bachelors degree from Jilin University (Changchun, China) in 2012, and his PhD from the Institute of Chemistry, Chinese Academy of Sciences (ICCAS, China) in 2017. After that, he moved to the Max Planck Institute of Colloids and Interfaces (MPIKG, Germany) working as an Alexander von Humboldt (AvH) Fellow. From 2021, he works as an Associate Professor at the Southern University of Science and Technology (SUSTech, China), and leads a research group of "Neuro-inspired Materials and Devices Lab". He has authored over 60 academic papers published in peer-reviewed journals and two book chapters, with citations of over 4000. His research interest lies in nanofluidic, ionic soft materials, and ionic energy/neuromorphic devices.

 

肖凯，南方科技大学生物医学工程系副教授，创新材料研究院兼职教授，博士生导师，洪堡学者，深圳市鹏城特聘教授。2012年于吉林大学获得学士学位，2017年于中国科学院化学研究所获得博士学位，2017年受洪堡基金会资助于德国马普胶体界面研究所从事博士后研究，2020年加入德国莱布尼茨固体与材料研究所从事博士后研究。2021年9月加入南方科技大学生物医学工程系。在Nat. Commun., Sci. Adv., Natl. Sci. Rev., Angew. Chem. Int. Ed., Adv. Mater., JACS等杂志发表学术论文60余篇，撰写Wiley 出版社百科全书《Kirk-Othmer Encyclopedia of Chemical Technology》等两章节。现任《Chinese Chemical Letter》和《Journal of Bionic Engineering》青年编委，入选2022年“全球前2%顶尖科学家”榜单，曾获德国“洪堡学者”奖学金、中国科学院优秀博士毕业论文、中国科学院院长优秀奖、朱李月华奖学金、唐敖庆化学奖学金、国际纳米科技与纳米医学峰会优秀青年科学家等荣誉和奖励。

 

【主持人】

 

 

贾艳伟

 

澳门大学

 

【研讨嘉宾】

 

 

王柳

 

中国科学技术大学

 

 

 

唐伟

 

中国科学院纳米能源研究所