直播时间：6月10日（周五） 20:00-21:30

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报告介绍：

Forward Engineering of Multi-cellular Biomachines

面向可持续未来的代谢工程与合成生物学

Hal Alper

The University of Texas at Austin

德克萨斯大学奥斯汀分校

Abstract

Recent technical advances are leading to a rapid transformation of the chemical palette available in cells, thus making it conceivable to produce nearly any organic molecule of interest—from biofuels to biopolymers to pharmaceuticals. However, these feats require the ability to “hijack” native cellular machinery and metabolism and navigate the complexity inherent in cellular regulation. This talk will cover examples of how microbial systems and enzyme can achieve the goal of sustainable chemical production and waste valorization. Examples include rewired cells for polymer precursors, plastic waste depolymerization, unconventional carbon utilization, and platform strain engineering for products such as polyketides and lipids. Throughout the talk, there will be a focus on the fundamental principles necessary to rewire metabolism and expedite the design-build-test-learn-deploy cycle of engineering.

最近的技术进步促使细胞中可用的化学调色板的快速转变，从而使生产从生物燃料到生物聚合物再到药物的几乎任何有机分子成为可能。然而，这些特性需要具有“劫持”原生细胞机制和新陈代谢的能力，以及驾驭细胞调节内在机制的复杂性。本次报告包括微生物系统和酶如何实现可持续化学生产和废物资源化。例如用于聚合物前驱体的重新布线的细胞、塑料废料解聚合、非常规碳利用以及用于诸如聚酮和脂类产品的平台应变工程。整个报告重点将放在重新连接新陈代谢和加快工程的设计-构建-测试-学习-部署周期所需的基本原则上。

Biography

Dr. Hal Alper is the Les and Sherri Stuewer Endowed Professor and Executive Director, of the Center for Biomedical Research Support at The University of Texas at Austin. He earned his Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology in 2006 and was a postdoctoral research associate at the Whitehead Institute for Biomedical Research from 2006-2008, and at Shire Human Genetic Therapies from 2007-2008. He is currently the Principal Investigator of the Laboratory for Cellular and Metabolic Engineering at The University of Texas at Austin where his lab focuses on metabolic and cellular engineering in the context of biofuel, biochemical, and biopharmaceutical production in an array of model host organisms. Dr. Alper has published over 135 articles and 8 book chapters and is the recipient of the Camille and Henry Dreyfus New Faculty Award in 2008, the Texas Exes Teaching Award in 2009, the DuPont Young Investigator Award in 2010, the Office of Naval Research Young Investigator Award in 2011, the UT Regents’ Outstanding Teaching Award in 2012, the 2013 Biotechnology and Bioengineering Daniel I.C. Wang Award, the Jay Bailey Young Investigator Award in Metabolic Engineering in 2014, the 2014 Camille Dreyfus Teacher-Scholar Award, 2015 Society for Industrial Microbiology and Biotechnology Young Investigator Award, 2016 ACS BIOT Young Investigator Award, 2016 UT-Austin Emerging Inventor of the Year Award, 2018 AIChE Allan P. Colburn Award, and 2019 Edith and Peter ODonnell Award in Engineering. He is a Fellow of both the National Academy of Inventors and The American Institute for Medical and Biological Engineering.

Hal Alper博士是德克萨斯大学奥斯汀分校生物医学研究支持中心的Les和 Sherri Stuewer教授，执行董事。他于2006年获得麻省理工学院化学工程博士学位，2006年至2008年担任Whitehead 生物医学研究所的博士后研究助理，2007年至2008年担任Shire 人类基因治疗的博士后研究助理。他目前是德克萨斯大学奥斯汀分校细胞与代谢工程实验室的首席研究员，他的实验室专注于代谢和细胞工程在生物燃料，生物化学和生物制药生产的背景下的一系列模式宿主生物。Alper博士发表了超过135篇文章和8个章节的书籍,获得2008年德瑞福斯青年教授奖, 2009年Texas Exes 教学奖, 2010年杜邦青年研究员奖, 2011年美国海军研究中心青年科学家奖, 2012年UT董事杰出教学奖,2013年生物技术与生物工程Daniel I.C. Wang奖，2014年代谢工程领域Jay Bailey青年研究员奖 ， 2014 年Camille Dreyfus教师学者奖, 2015 年工业微生物学与生物技术学会青年研究员奖, 2016 年ACS BIOT 青年研究员奖, 2016年 UT-Austin年度新兴发明家奖, 2018年 AIChE Allan P. Colburn 奖, 2019 年Edith and Peter ODonnell 工程奖。他是美国发明家学会以及美国医学和生物工程研究所的会士。

Keywords

Metabolic Engineering 代谢工程

Synthetic Biology 合成生物学

Sustainable 可持续

Microbial systems 微生物系统

Enzyme 酶

同时，本次讲座也邀请了来自北京大学的张海霞教授担纲主持。来自德克萨斯大学奥斯汀分校Nicholas A Peppas教授和来自清华大学的陈国强教授作为嘉宾，以及来自北京大学的项泽华博士作为挑战者。精彩不断，敬请期待！

At the same time, this lecture invited Professor Haixia Zhang from Peking University as host. Professor Nicholas A Peppas from University of Texas at Austin and professor Guoqiang Chen from Tsinghua University as guests, and Dr Zehua Xiang from Peking University as X-challenger. In 2022, iCANX will continue to work hard to serve scientific exchanges and provide a top platform for global academic exchanges. Please look forward to it!