来源:科学网 www.sciencenet.cn 发布时间:2012-12-4 15:34:48
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Magnetically Enhanced

Fluorescence: Signal Amplification by Magnetic Force on Polydiacetylene Supramolecules for Detection of Prostate Cancer

 
SMLL-2: The cover picture shows a method for enhanced detection of prostate cancer on polydiacetylene (PDA) vesicle chips. External stimuli, including heat, solvents, mechanical force, pH, and ligand–receptor interactions, induce the perturbation of the PDA liposome backbone, which generates red fluorescence emission. Magnetic beads (shown as black) and a permanent magnet (under the chip) are used on the PDA vesicle chip to further enhance the red fluorescence. This strategy involves amplification of the fluorescent signal by combining the primary immune reaction of the antigen–antibody, the sandwich method of the polyclonal antibody-conjugated magnetic beads, and the amplification of the fluorescent signal due to the increased external mechanical pressure due to the magnetic attraction between the magnetic beads and permanent magnet. This strategy can be applied to general antibody-based PDA vesicle chips to detect clinically important biomarkers for disease diagnosis. For further information, please read the Communication “Signal Amplification by Magnetic Force on PolydiacetyleneSupramolecules for Detection of Prostate Cancer” by S. J. Sim and co-workers
 
图评:很漂亮的设计,很棒的材质处理。Small封面的两层嵌套设计经常让人有点懊恼,但是这张图巧妙的利用了嵌套设计将作品中的细节处理和关系都充分表现出来。内图区域将磁力线和磁珠对细胞的作用用物理的方式来阐述,黑色的磁珠上面光影设计很充分,让它的立体感和重量感都很到位,看图的观众能感觉到从画面中传递出来的挤压感,荧光感觉的磁力线也被装饰了一番,摆脱了以往的线条圈的感觉,轻盈妩媚,使得整个画面有一种女生对时尚的追求感,而没有灰暗和板正的学术压力。外面套图上虽然不是很清楚,但是将图像材质的特色体现出来让人感觉到似乎能摸到的温润。设计师对三维质感的塑造能力非常高。
 
 
 
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