标题：Highly Pathogenic H5N1 Influenza Virus Infection in Migratory Birds
来源：《科学》2005年309卷5738期1206页
作者：中国农业大学兽医学院 Jin-Hua Liu（刘金华）, Xing-Lin Zhang（张兴林）, De-Ming Zhao（赵德明）
中科院微生物研究所 Jun-Cai Ma（马俊才）, Wen-Jun Liu（刘文军）, Fu Gao（高福）
中科院动物研究所 Fu-Min Lei（雷富民）
中科院微生物研究所、中科院研究生院 Hai-Xia Xiao（校海霞）, Gui-Hua Wang, You-Jun Feng（冯友军）
军事医学科学院 Qing-Yu Zhu（祝庆余）
中科院北京基因组研究所 Xiao-Wei Zhang（张小伟）, Jian Wang（汪建）
Research Fronts: HIGHLY PATHOGENIC H5N1 INFLUENZA VIRUS INFECTION; HIGHLY PATHOGENIC H5N1 INFLUENZA VIRUSES; HIGHLY PATHOGENIC H5N1 AVIAN INFLUENZA; HIGHLY PATHOGENIC AVIAN INFLUENZA; POTENTIALLY PANDEMIC H5N1 INFLUENZA VIRUS
领域：临床医学
摘要：H5N1 avian influenza virus (AIV) has emerged as a pathogenic entity for a variety of species, including humans, in recent years. Here we report an outbreak among migratory birds on Lake Qinghaihu, China, in May and June 2005, in which more than a thousand birds were affected. Pancreatic necrosis and abnormal neurological symptoms were the major clinical features. Sequencing of the complete genomes of four H5N1 AIV strains revealed them to be reassortants related to a peregrine falcon isolate from Hong Kong and to have known highly pathogenic characteristics. Experimental animal infections reproduced typical highly pathogenic AIV infection symptoms and pathology.
