杜克大学Sudarshan Rajagopal小组的最新研究揭示了β-抑制素凝聚物调节G蛋白偶联受体功能。相关论文于2026年5月27日发表在《自然》杂志上。

在这里，该课题组人员发现β-阻滞蛋白经过液-液相分离，形成冷凝物，调节GPCR的功能。该团队发现冷凝是特异性的视觉抑制蛋白和β-抑制蛋白，并证明β-抑制蛋白寡聚化发生在GPCR附近，以调节GPCR的功能，如内化和信号传导。他们的工作为β-抑制蛋白凝聚物作为GPCR功能的调节剂提供了一个范例，液-液相分离是GPCR信号区隔化的重要启动子。

据悉，β-阻滞蛋白1和2是调节G蛋白偶联受体（GPCR）信号传导的多功能衔接蛋白，GPCR是最大的一类受体，影响生理学的几乎所有方面，是最常见的药物靶点之一。尽管β-阻滞蛋白与许多GPCR中的一系列信号效应物相互作用，但尚不清楚β-阻滞蛋白如何促进这些不同的功能。

附：英文原文

Title: β-Arrestin condensates regulate G-protein-coupled receptor function

Author: Anderson, Preston J., Xiao, Peng, Zhong, Ya-Ni, Kaakati, Adam N., Alfonso-DeSouza, Juliana, Patino, Alejandra, Ahn, Andrew, Jassal, Chanpreet, Zhang, Tianyao, Zhang, Chao, Yu, Kexin, Qi, Lei, Ding, Wei, Liu, Samuel, Pani, Biswaranjan, Krishnan, Athmika, Chen, Oscar, Strawn, Joseph, Snyder, Joshua C., Sun, Jin-Peng, Rajagopal, Sudarshan

Issue&Volume: 2026-05-27

Abstract: β-Arrestins 1 and 2 are multifunctional adaptor proteins1 that regulate the signalling of G-protein-coupled receptors (GPCRs), the largest class of receptors, which impact nearly all aspects of physiology and are one of the most common drug targets2. Although β-arrestins interact with a wide array of signalling effectors at many GPCRs, it is unclear how β-arrestins promote such varied functions. Here we show that β-arrestins undergo liquid–liquid phase separation, forming condensates that regulate GPCR function. We show that condensation is specific to visual arrestins and β-arrestins, and demonstrate that β-arrestin oligomerization occurs in proximity to the GPCR to regulate GPCR functions such as internalization and signalling. Our work provides a paradigm for β-arrestin condensates as regulators of GPCR function, with liquid–liquid phase separation serving as an important promoter of signalling compartmentalization at GPCRs.

DOI: 10.1038/s41586-026-10539-y

Source: https://www.nature.com/articles/s41586-026-10539-y