近日，南方科技大学谭斌团队报道了不对称光催化[4+2]环加成的接力能量传递模式。该研究于2026年5月21日发表在《科学》杂志上。

在不对称能量转移光催化中，直接掺入常规手性催化剂在几种转化中实现了令人满意的对映体控制。然而，这种模式的效率甚至可行性仍然受到不可避免的催化剂介导的空间分离所产生的能量转移障碍的限制。

为了克服这一被低估的限制，研究组设计了一种中继能量转移催化模式，其中催化剂充当光敏剂和底物之间能量转移的桥梁。在这一概念的指导下，研究组设计了一类能够提供高三重态能量的手性能量转移酸催化剂。这些催化剂有效地规避了喹啉和烯烃之间脱芳烃[4+2]环化过程中对酸活化剂的固有化学计量依赖性。侧臂的可调性和催化位点与手性源的接近度优化了区域、非对映和对映选择性。

附：英文原文

Title: A relay energy transfer paradigm for asymmetric photocatalyzed [4+2] cycloadditions

Author: Yong-Bin Wang, Yi-An Xu, Cheng Li, Gang-Ya Cheng, Shao-Hua Xiang, Bin Tan

Issue&Volume: 2026-05-21

Abstract: In asymmetric energy transfer photocatalysis, direct incorporation of conventional chiral catalysts has achieved satisfactory enantiocontrol in several transformations. However, the efficiency and even feasibility of this mode are still limited by the energy transfer barrier that arises from the inevitable catalyst-mediated spatial segregation. To overcome this underappreciated constraint, we designed a relay energy transfer catalytic mode in which the catalyst acts as a bridge for energy transfer between the photosensitizer and the substrate. Guided by this concept, we engineered a class of chiral energy transfer acid catalysts capable of delivering high triplet energy. These catalysts effectively circumvent the inherent stoichiometric dependence on acid activators in dearomative [4+2] cyclization between quinolines and alkenes. The tunability of side arms and the proximity of the catalytic site to the chiral source optimize regio-, diastereo-, and enantioselectivities.

DOI: aeb8506

Source: https://www.science.org/doi/10.1126/science.aeb8506