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可改善心脏功能和组织修复的心脏外膜装置
作者:小柯机器人 发布时间:2021/3/16 14:18:33

上海交通大学医学院Xiaofeng Ye、Qiang Zhao和东华大学Zhengwei You合作,研发了可灌注、多功能心外膜装置,可改善心脏功能和组织修复。该项研究成果发表在2021年3月15日出版的《自然—医学》上

研究人员设计了一种可灌注的多功能心外膜装置(PerMed),该装置由可生物降解的弹性贴片(BEP)、可渗透的分层微通道网络(PHM)和能够从皮下植入泵中输送治疗药物的系统构成。BEP植入心外膜后主要为心室重构提供机械刺激,而PHM则促进血管生成并允许修复细胞的浸润。

在心肌梗死大鼠模型中,植入PerMed改善了心室功能。当与皮下泵相连时,PerMed可使血小板源性生长因子-BB有针对性、持续且稳定地释放,与没有该泵的设备相比,其可增强心脏修复的功效。研究人员还验证了在猪中进行微创外科PerMed植入的可行性,证明了其具有临床转化和治疗心脏病的潜力。

研究人员表示,尽管在心肌梗死(MI)后进行心脏修复的技术有所进步,但仍需要研发新的综合治疗方法。

附:英文原文

Title: A perfusable, multifunctional epicardial device improves cardiac function and tissue repair

Author: Shixing Huang, Dong Lei, Qi Yang, Yang Yang, Chenyu Jiang, Hongpeng Shi, Bei Qian, Qiang Long, Wenyi Chen, Youming Chen, Lan Zhu, Wenjie Yang, Lan Wang, Wangxi Hai, Qiang Zhao, Zhengwei You, Xiaofeng Ye

Issue&Volume: 2021-03-15

Abstract: Despite advances in technologies for cardiac repair after myocardial infarction (MI), new integrated therapeutic approaches still need to be developed. In this study, we designed a perfusable, multifunctional epicardial device (PerMed) consisting of a biodegradable elastic patch (BEP), permeable hierarchical microchannel networks (PHMs) and a system to enable delivery of therapeutic agents from a subcutaneously implanted pump. After its implantation into the epicardium, the BEP is designed to provide mechanical cues for ventricular remodeling, and the PHMs are designed to facilitate angiogenesis and allow for infiltration of reparative cells. In a rat model of MI, implantation of the PerMed improved ventricular function. When connected to a pump, the PerMed enabled targeted, sustained and stable release of platelet-derived growth factor-BB, amplifying the efficacy of cardiac repair as compared to the device without a pump. We also demonstrated the feasibility of minimally invasive surgical PerMed implantation in pigs, demonstrating its promise for clinical translation to treat heart disease. Implantation of a perfusable device into the epicardium enables delivery of therapeutic agents and infiltration of reparative cells into the heart, amplifying the therapeutic effects of FGF-23 in a rat model of myocardial infarction.

DOI: 10.1038/s41591-021-01279-9

Source: https://www.nature.com/articles/s41591-021-01279-9

期刊信息

Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:30.641
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex