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抗原结合价影响B细胞反应和分化
作者:小柯机器人 发布时间:2020/8/28 16:54:26

美国拉霍亚免疫研究所(LJI)Shane Crotty和斯克里普斯研究中心William R. Schief研究小组合作,探究了抗原结合价对B细胞反应和体内分化的多方面影响。这一研究成果发表在2020年8月27日的《免疫》。

研究人员利用结合价在1到60范围内的HIV免疫原探究了B细胞应答不同阶段抗原结合价的作用。高度多聚的免疫原优先快速激活同源B细胞,几乎没有亲和力偏好性。这导致转录因子IRF4(干扰素调节因子4)和Bcl6早期被强烈诱导,从而以CD4+T细胞依赖性方式引起早期滤泡外浆细胞和生发中心反应,包括具有广泛亲和力的B细胞。

低价抗原诱导较弱的效应B细胞反应,优先招募高亲和力B细胞。 因此,抗原结合价对B细胞应答具有多方面的影响,并且可以指示体内B细胞亲和力的阈值和竞争态势,这也影响疫苗设计。

附:英文原文

Title: Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

Author: Yu Kato, Robert K. Abbott, Brian L. Freeman, Sonya Haupt, Bettina Groschel, Murillo Silva, Sergey Menis, Darrell J. Irvine, William R. Schief, Shane Crotty

Issue&Volume: 2020-08-27

Abstract: How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated the role of antigen valency during different phases of B cell responses in vivo. Highly multimerized immunogens preferentially rapidly activated cognate B cells, with little affinity discrimination. This led to strong early induction of the transcription factors IRF4 (interferon regulatory factor 4) and Bcl6, driving both early extrafollicular plasma cell and germinal center responses, in a CD4+ T-cell-dependent manner, involving B cells with a broad range of affinities. Low-valency antigens induced smaller effector B cell responses, with preferential recruitment of high-affinity B cells. Thus, antigen valency has multifaceted effects on B cell responses and can dictate affinity thresholds and competitive landscapes for B cells in vivo, with implications for vaccine design.

DOI: 10.1016/j.immuni.2020.08.001

Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30334-4

期刊信息

Immunity:《免疫》,创刊于1994年。隶属于细胞出版社,最新if:21.522
官方网址:https://www.cell.com/immunity/home
投稿链接:https://www.editorialmanager.com/immunity/default.aspx