美国国立癌症研究所Chuan Wu团队发现,白介素33促进肠嗜铬细胞释放5-羟色胺,从而调控肠道稳态。这一研究成果于2020年11月20日在线发表在国际学术期刊《免疫》上。
Title: Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis
Author: Zuojia Chen, Jialie Luo, Jian Li, Girak Kim, Andy Stewart, Joseph F. Urban, Yuefeng Huang, Shan Chen, Ling-Gang Wu, Alexander Chesler, Giorgio Trinchieri, Wei Li, Chuan Wu
Issue&Volume: 2020-11-20
Abstract: The gastrointestinal tract is known as the largest endocrine organ that encountersand integrates various immune stimulations and neuronal responses due to constantenvironmental challenges. Enterochromaffin (EC) cells, which function as chemosensorson the gut epithelium, are known to translate environmental cues into serotonin (5-HT)production, contributing to intestinal physiology. However, how immune signals participatein gut sensation and neuroendocrine response remains unclear. Interleukin-33 (IL-33)acts as an alarmin cytokine by alerting the system of potential environmental stresses.We here demonstrate that IL-33 induced instantaneous peristaltic movement and facilitatedTrichuris muris expulsion. We found that IL-33 could be sensed by EC cells, inducing release of 5-HT.IL-33-mediated 5-HT release activated enteric neurons, subsequently promoting gutmotility. Mechanistically, IL-33 triggered calcium influx via a non-canonical signalingpathway specifically in EC cells to induce 5-HT secretion. Our data establish an immune-neuroendocrineaxis in calibrating rapid 5-HT release for intestinal homeostasis.
DOI: 10.1016/j.immuni.2020.10.014
Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30455-6
Immunity:《免疫》,创刊于1994年。隶属于细胞出版社,最新IF:21.522
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