当前位置:科学网首页 > 小柯机器人 >详情
白介素33促进肠嗜铬细胞释放5-羟色胺
作者:小柯机器人 发布时间:2020/11/23 16:47:58

美国国立癌症研究所Chuan Wu团队发现,白介素33促进肠嗜铬细胞释放5-羟色胺,从而调控肠道稳态。这一研究成果于2020年11月20日在线发表在国际学术期刊《免疫》上。

研究人员发现,白细胞介素33(IL-33)引起瞬时蠕动并促进Trichuris muris排出。研究人员发现,肠嗜铬细胞(EC)可以检测到IL-33,从而诱导5-羟色胺(5-HT)的释放。IL-33介导的5-HT释放激活的肠神经元,随后促进肠蠕动。从机制上讲,IL-33通过非经典的信号途径触发了钙流入,特别是在EC细胞中诱导了5-HT的分泌。这些数据在校准肠内稳态5-HT的快速释放方面建立了免疫神经内分泌轴。
 
据介绍,胃肠道是最大的内分泌器官,由于持续的环境挑战,它会遇到并整合各种免疫刺激和神经元反应。EC在肠道上皮细胞中起化学传感器的作用,可将环境提示转化为5-HT产生,从而促进肠道生理。但是,尚不清楚免疫信号如何参与肠道感觉和神经内分泌反应。IL-33通过警告系统潜在的环境压力,充当警报蛋白细胞因子。
 
附:英文原文

Title: Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis

Author: Zuojia Chen, Jialie Luo, Jian Li, Girak Kim, Andy Stewart, Joseph F. Urban, Yuefeng Huang, Shan Chen, Ling-Gang Wu, Alexander Chesler, Giorgio Trinchieri, Wei Li, Chuan Wu

Issue&Volume: 2020-11-20

Abstract: The gastrointestinal tract is known as the largest endocrine organ that encountersand integrates various immune stimulations and neuronal responses due to constantenvironmental challenges. Enterochromaffin (EC) cells, which function as chemosensorson the gut epithelium, are known to translate environmental cues into serotonin (5-HT)production, contributing to intestinal physiology. However, how immune signals participatein gut sensation and neuroendocrine response remains unclear. Interleukin-33 (IL-33)acts as an alarmin cytokine by alerting the system of potential environmental stresses.We here demonstrate that IL-33 induced instantaneous peristaltic movement and facilitatedTrichuris muris expulsion. We found that IL-33 could be sensed by EC cells, inducing release of 5-HT.IL-33-mediated 5-HT release activated enteric neurons, subsequently promoting gutmotility. Mechanistically, IL-33 triggered calcium influx via a non-canonical signalingpathway specifically in EC cells to induce 5-HT secretion. Our data establish an immune-neuroendocrineaxis in calibrating rapid 5-HT release for intestinal homeostasis.

DOI: 10.1016/j.immuni.2020.10.014

Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30455-6

期刊信息

Immunity:《免疫》,创刊于1994年。隶属于细胞出版社,最新IF:21.522
官方网址:https://www.cell.com/immunity/home
投稿链接:https://www.editorialmanager.com/immunity/default.aspx