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重症COVID-19患者具有促炎性IgG Fc结构
作者:小柯机器人 发布时间:2020/11/10 22:10:25

美国斯坦福大学Taia T. Wang研究组发现,重症COVID-19患者具有促炎性IgG Fc结构。该研究于2020年11月9日在线发表于国际一流学术期刊《自然—免疫学》。

研究人员发现,COVID-19重症患者产生了独特的血清学特征,包括具有岩藻糖基化Fc聚糖的IgG1增加。SARS-CoV-2 IgG的这种Fc修饰增强了与活化Fcγ受体FcγRIIIa的相互作用;当结合免疫复合物时,Fc岩藻糖基化增强了单核细胞产生的炎性细胞因子(包括白介素6和肿瘤坏死因子)。这些结果表明,COVID-19中的疾病严重程度与促炎性IgG Fc结构(包括岩藻糖基化IgG1)相关。
 
据介绍,SARS-CoV-2感染可导致COVID-19,从而表现出从轻度疾病到危及生命的肺炎和多器官衰竭。严重的COVID-19的特征是炎性信号,包括高水平的炎性细胞因子、肺泡炎性浸润物和血管微血栓。
 
附:英文原文

Title: Proinflammatory IgG Fc structures in patients with severe COVID-19

Author: Saborni Chakraborty, Joseph Gonzalez, Karlie Edwards, Vamsee Mallajosyula, Anthony S. Buzzanco, Robert Sherwood, Cindy Buffone, Nimish Kathale, Susan Providenza, Markus M. Xie, Jason R. Andrews, Catherine A. Blish, Upinder Singh, Haley Dugan, Patrick C. Wilson, Tho D. Pham, Scott D. Boyd, Kari C. Nadeau, Benjamin A. Pinsky, Sheng Zhang, Matthew J. Memoli, Jeffery K. Taubenberger, Tasha Morales, Jeffrey M. Schapiro, Gene S. Tan, Prasanna Jagannathan, Taia T. Wang

Issue&Volume: 2020-11-09

Abstract: Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure. Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi. Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans. This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor. These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.

DOI: 10.1038/s41590-020-00828-7

Source: https://www.nature.com/articles/s41590-020-00828-7

期刊信息

Nature Immunology:《自然—免疫学》,创刊于2000年。隶属于施普林格·自然出版集团,最新IF:23.53
官方网址:https://www.nature.com/ni/
投稿链接:https://mts-ni.nature.com/cgi-bin/main.plex