美国哈佛医学院Dan H. Barouch团队发现,疫苗抗体的被动转移可防止猕猴感染SIV。该项研究成果发表在2020年10月1日出版的《细胞》杂志上。
Title: Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques
Author: Galit Alter, Wen-Han Yu, Abishek Chandrashekar, Erica N. Borducchi, Khader Ghneim, Ashish Sharma, Rebecca Nedellec, Katherine R. McKenney, Caitlyn Linde, Thomas Broge, Todd J. Suscovich, Tom Linnekin, Peter Abbink, Noe B. Mercado, Joseph P. Nkolola, Katherine McMahan, Esther A. Bondzie, Venous Hamza, Lauren Peter, Nicole Kordana, Shant Mahrokhian, Michael S. Seaman, Wenjun Li, Mark G. Lewis, Douglas A. Lauffenburger, Lars Hangartner, Rafick-Pierre Sekaly, Dan H. Barouch
Issue&Volume: 2020/10/01
Abstract: Several HIV-1 and SIV vaccine candidates have shown partial protection against viralchallenges in rhesus macaques. However, the protective efficacy of vaccine-elicitedpolyclonal antibodies has not previously been demonstrated in adoptive transfer studiesin nonhuman primates. In this study, we show that passive transfer of purified antibodiesfrom vaccinated macaques can protect naive animals against SIVmac251 challenges. Wevaccinated 30 rhesus macaques with Ad26-SIV Env/Gag/Pol and SIV Env gp140 proteinvaccines and assessed the induction of antibody responses and a putative protectivesignature. This signature included multiple antibody functions and correlated withupregulation of interferon pathways in vaccinated animals. Adoptive transfer of purifiedimmunoglobulin G (IgG) from the vaccinated animals with the most robust protectivesignatures provided partial protection against SIVmac251 challenges in naive recipientrhesus macaques. These data demonstrate the protective efficacy of purified vaccine-elicitedantiviral antibodies in this model, even in the absence of virus neutralization.
DOI: 10.1016/j.cell.2020.08.033
Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31075-8