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研究揭示被SARS-CoV-2感染的恒河猴中血管疾病和血栓形成的原因
作者:小柯机器人 发布时间:2020/10/12 17:00:00

美国贝斯以色列女执事医疗中心Dan H. Barouch小组揭示被SARS-CoV-2感染的恒河猴中血管疾病和血栓形成的原因。相关论文于2020年10月9日在线发表在《细胞》杂志上。

研究人员证明了感染SARS-CoV-2的人类和恒河猴的肺组织病理学切片中内皮破坏和血管血栓的形成。为了定义与恒河猴SARS-CoV-2发病机理相关的关键分子途径,研究人员进行了支气管肺泡灌洗(BAL)和外周血的转录组分析以及血清的蛋白质组学分析。研究人员观察到肺中巨噬细胞浸润以及巨噬细胞、补体、血小板活化、血栓形成和促炎性标志物上调,包括C反应蛋白、MX1、IL-6、IL-1、IL-8、TNFα和NF-κB。
 
这些结果提出了一种模型,即炎症和血栓形成途径之间的关键相互作用导致了SARS-CoV-2引发的血管疾病。这些的发现提示了COVID-19的潜在治疗靶标。
 
据了解,COVID-19大流行已导致世界各地广泛的发病和死亡。在人类中,驱动SARS-CoV-2发病机制的临床特征包括炎症和血栓形成,但这些过程的机制细节尚待确定。
 
附:英文原文

Title: Vascular Disease and Thrombosis in SARS-CoV-2 Infected Rhesus Macaques

Author: Malika Aid, Kathleen Busman-Sahay, Samuel J. Vidal, Zoltan Maliga, Stephen Bondoc, Carly Starke, Margaret Terry, Connor A. Jacobson, Linda Wrijil, Sarah Ducat, Olga R. Brook, Andrew D. Miller, Maciel Porto, Kathryn L. Pellegrini, Maria Pino, Timothy N. Hoang, Abishek Chandrashekar, Shivani Patel, Kathryn Stephenson, Steven E. Bosinger, Hanne Andersen, Mark G. Lewis, Jonathan L. Hecht, Peter K. Sorger, Amanda J. Martinot, Jacob D. Estes, Dan H. Barouch

Issue&Volume: 2020-10-09

Abstract: The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world. Clinical features that drive SARS-CoV-2 pathogenesis in humans include inflammation and thrombosis, but the mechanistic details underlying these processes remain to be determined. In this study, we demonstrate endothelial disruption and vascular thrombosis in histopathologic sections of lungs from both humans and rhesus macaques infected with SARS-CoV-2. To define key molecular pathways associated with SARS-CoV-2 pathogenesis in macaques, we performed transcriptomic analyses of bronchoalveolar lavage (BAL) and peripheral blood and proteomic analyses of serum. We observed macrophage infiltrates in lung and upregulation of macrophage, complement, platelet activation, thrombosis, and proinflammatory markers, including C-reactive protein, MX1, IL-6, IL-1, IL-8, TNFα, and NF-κB. These results suggest a model in which critical interactions between inflammatory and thrombosis pathways lead to SARS-CoV-2 induced vascular disease. Our findings suggest potential therapeutic targets for COVID-19.

DOI: 10.1016/j.cell.2020.10.005

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31311-8

期刊信息
Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/