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研究揭示内脏脂肪的疾病风险相关性
作者:小柯机器人 发布时间:2019/9/10 16:58:34

瑞典乌普萨拉大学Åsa Johansson和Torgny Karlsson等研究人员合作揭示了遗传因素对内脏肥胖的贡献及其与心血管和代谢疾病的关系。这一研究成果2019年9月发表在《自然—医学》上。

研究人员使用UK Biobank队列开发了内脏脂肪组织(VAT,即储存在内脏周围的脂肪)质量的性别分层非线性预测模型(确定系数= 0.76;典型95%置信区间(CI)= 0.74-0.78)。研究人员对预测的VAT质量进行了全基因组关联研究,并确定了102个新的内脏肥胖位点。预测的VAT质量与高血压、心脏病发作/心绞痛、2型糖尿病和高脂血症的风险增加有关,孟德尔随机分析显示内脏脂肪是所有四种疾病的致病风险因素。特别是,2型糖尿病患者之间的因果关系差异很大,女性的比值比为7.34(95%CI = 4.48-12.0),在男性中比值比为2.50(95%CI = 1.98-3.14)。这些研究结果加强了内脏肥胖作为潜在独立危险因素的作用,特别是对于白人女性的2型糖尿病。其他队列中的独立验证对于确定研究结果是否可以转化到其他种族或英国以外是必要的。

据悉,内脏脂肪组织(VAT)被认为是心血管和代谢疾病以及全因、心血管特异性和癌症特异性死亡的独立危险因素。然而,遗传对VAT的贡献以及与疾病相关的影响在很大程度上尚未探究,因为需要先进的成像技术来准确测量VAT。

附:英文原文

Title: Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease

Author: Torgny Karlsson, Mathias Rask-Andersen, Gang Pan, Julia Hglund, Claes Wadelius, Weronica E. Ek, Åsa Johansson

Issue&Volume:Volume 25 Issue 9

Abstract: Visceral adipose tissue (VAT)fat stored around the internal organshas been suggested as an independent risk factor for cardiovascular and metabolic disease13, as well as all-cause, cardiovascular-specific and cancer-specific mortality4,5. Yet, the contribution of genetics to VAT, as well as its disease-related effects, are largely unexplored due to the requirement for advanced imaging technologies to accurately measure VAT. Here, we develop sex-stratified, nonlinear prediction models (coefficient of determination=0.76; typical 95%confidence interval (CI)=0.740.78) for VAT mass using the UK Biobank cohort. We performed a genome-wide association study for predicted VAT mass and identified 102 novel visceral adiposity loci. Predicted VAT mass was associated with increased risk of hypertension, heart attack/angina, type 2 diabetes and hyperlipidemia, and Mendelian randomization analysis showed visceral fat to be a causal risk factor for all four diseases. In particular, a large difference in causal effect between the sexes was found for type 2 diabetes, with an odds ratio of 7.34 (95%CI=4.4812.0) in females and an odds ratio of 2.50 (95%CI=1.983.14) in males. Our findings bolster the role of visceral adiposity as a potentially independent risk factor, in particular for type 2 diabetes in Caucasian females. Independent validation in other cohorts is necessary to determine whether the findings can translate to other ethnicities, or outside the UK. Analysis of the UK Biobank reveals new genetic loci associated with estimated visceral adipose tissue (VAT) mass, and suggests that VAT is potentially an independent risk factor for various cardiovascular and metabolic diseases, such as hypertension and type 2 diabetes.

DOI: 10.1038/s41591-019-0563-7

Source:https://www.nature.com/articles/s41591-019-0563-7

 

期刊信息

Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:30.641
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex