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脂质在我们增重或减肥过程中发生了什么
作者:小柯机器人 发布时间:2019/9/10 15:53:08

近日,瑞典卡罗林斯卡学院K. L. Spalding、P. Arner团队在脂肪代谢与体重的长期变化研究领域取得进展。相关论文2019年9月发表在《自然—医学》上。

在十六年时间里,研究小组跟踪测定了成年人脂肪细胞脂质的周转率(储存和清除脂质的能力)。方法是测量脂肪组织甘油三酯中含有放射标记的14C。随着人们年龄的增长,脂质去除率下降,未能相互调节脂质摄取率,从而导致体重增加。体重的大幅度下降并不是由脂质去除的变化引起的,而是由脂肪组织中脂质吸收的速度引起的。此外,基线去脂率低的个体在减肥后更有可能保持体重稳定。因此,脂质代谢适应可能对维持明显的减肥很重要。综上所述,脂肪脂质代谢是人类超重/肥胖长期发展和减肥维持的重要因素。

研究人员表示,全球范围内的肥胖流行,使得了解脂质周转率如何调节脂肪组织质量变得非常重要。横断面研究表明,过多的身体脂肪与降低脂肪脂质去除率有关。脂质周转率在人的一生中是恒定的、还是在长期增重或减重过程中发生了变化,目前尚不清楚。

附:英文原文

Title: Adipose lipid turnover and long-term changes in body weight

Author: P. Arner, S. Bernard, L. Appelsved, K.-Y. Fu, D. P. Andersson, M. Salehpour, A. Thorell, M. Rydn, K. L. Spalding

Issue&Volume:Volume 25 Issue 9

Abstract: The worldwide obesity epidemic1 makes it important to understand how lipid turnover (the capacity to store and remove lipids) regulates adipose tissue mass. Cross-sectional studies have shown that excess body fat is associated with decreased adipose lipid removal rates2,3. Whether lipid turnover is constant over the life span or changes during long-term weight increase or loss is unknown. We determined the turnover of fat cell lipids in adults followed for up to 16 years, by measuring the incorporation of nuclear bomb test-derived 14C in adipose tissue triglycerides. Lipid removal rate decreases during aging, with a failure to reciprocally adjust the rate of lipid uptake resulting in weight gain. Substantial weight loss is not driven by changes in lipid removal but by the rate of lipid uptake in adipose tissue. Furthermore, individuals with a low baseline lipid removal rate are more likely to remain weight-stable after weight loss. Therefore, lipid turnover adaptation might be important for maintaining pronounced weight loss. Together these findings identify adipose lipid turnover as an important factor for the long-term development of overweight/obesity and weight loss maintenance in humans. Long-term changes in body weight are determined by rates of adipose lipid turnover.

DOI: 10.1038/s41591-019-0565-5

Source:https://www.nature.com/articles/s41591-019-0565-5

期刊信息

Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:30.641
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex