当前位置:科学网首页 > 小柯机器人 >详情
研究总结干扰素靶基因的表达特征
作者:小柯机器人 发布时间:2019/11/20 15:29:16

美国康奈尔大学Lionel B. Ivashkiv等研究人员回顾性总结了在健康和疾病中干扰素靶基因表达和表观基因组特征。相关综述论文2019年11月19日在线发表于《自然—免疫学》杂志。

研究人员表示,多种I型干扰素和干扰素-γ(IFN-γ)在生理条件下表达,并在压力和感染以及自身炎症和自身免疫性疾病中增加。干扰素激活Jak–STAT信号传导途径,并诱导经典的干扰素刺激基因(ISG)编码对抗病毒应答、抗原呈递、自身免疫和炎症至关重要的分子的重叠表达模式,称为“干扰素特征”。

目前清楚的是,干扰素还可以通过激活潜在的增强子和“标记”染色质来诱导“干扰素表观基因组特征”,从而重新编程细胞对环境线索的反应。干扰素表观基因组学特征影响ISG和其他基因组,包括编码炎症分子的转录因子NF-κB的典型靶标,并参与免疫细胞的启动、耐受性和先天免疫记忆的训练。

研究人员系统性回顾了通过干扰素特征和干扰素表观基因组特征生成的机制,以及这些特征在稳态和自身免疫性疾病(包括系统性红斑狼疮、类风湿性关节炎和系统性硬化症)中的表达和功能后果。

附:英文原文

Title: Interferon target-gene expression and epigenomic signatures in health and disease

Author: Franck J. Barrat, Mary K. Crow, Lionel B. Ivashkiv

Issue&Volume: 2019-11-19

Abstract: Multiple type I interferons and interferon-γ (IFN-γ) are expressed under physiological conditions and are increased by stress and infections, and in autoinflammatory and autoimmune diseases. Interferons activate the Jak–STAT signaling pathway and induce overlapping patterns of expression, called ‘interferon signatures’, of canonical interferon-stimulated genes (ISGs) encoding molecules important for antiviral responses, antigen presentation, autoimmunity and inflammation. It has now become clear that interferons also induce an ‘interferon epigenomic signature’ by activating latent enhancers and ‘bookmarking’ chromatin, thus reprogramming cell responses to environmental cues. The interferon epigenomic signature affects ISGs and other gene sets, including canonical targets of the transcription factor NF-κB that encode inflammatory molecules, and is involved in the priming of immune cells, tolerance and the training of innate immune memory. Here we review the mechanisms through which interferon signatures and interferon epigenomic signatures are generated, as well as the expression and functional consequences of these signatures in homeostasis and autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis.

DOI: 10.1038/s41590-019-0466-2

Source: https://www.nature.com/articles/s41590-019-0466-2

期刊信息

Nature Immunology:《自然—免疫学》,创刊于2000年。隶属于施普林格·自然出版集团,最新IF:23.53
官方网址:https://www.nature.com/ni/
投稿链接:https://mts-ni.nature.com/cgi-bin/main.plex